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Clinical Nursing Research, Vol. 12, No. 1, 49-68 (2003)
DOI: 10.1177/1054773803238740

Physiological and Psychological Markers Associated with HIV-Related Fatigue

Julie Barroso

University of North Carolina School of Nursing

John R. Carlson

University of North Carolina School of Nursing

Janet Meynell

Burnsville, NC

Fatigue is among the most common and debilitating complaints of HIV-positive individuals. These data are part of a larger exploratory study investigating the relationships of selected psychological and physiological factors among 40 participants with HIV-related fatigue. Fatigue severity was measured using the HIV-Related Fatigue Scale. Fatigue was correlated with depression (r = .40, p <.01), state anxiety (r = .40, p < .01), and trait anxiety (r = .46, p < .01). Of the physiological factors, there were three statistically significant correlations: thyroid-stimulating hormone was negatively correlated with fatigue severity (r = -.36, p = .02), and platelets (r = .35, p = .03) and alkaline phosphatase (r = .27, p = .09) were positively correlated with fatigue severity. There were no correlations between fatigue severity and CD4 count (r = -.16, p = .31) or fatigue severity and HIV viral load levels (r = .031, p = .84). Even among the group with excellent viral suppression, fatigue scores were still very high for many participants.

Key Words: HIV • fatigue • physiological markers • psychological markers


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K. D. Phillips, R. L. Sowell, M. Rojas, A. Tavakoli, L. J. Fulk, and G. A. Hand
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