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Clinical Nursing Research, Vol. 16, No. 2, 153-163 (2007)
DOI: 10.1177/1054773806296429
© 2007 SAGE Publications

Intrasubject Medication Adherence Patterns

Cynthia L. Russell

University of Missouri-Columbia

Vicki S. Conn

University of Missouri-Columbia

Catherine Ashbaugh

University of Missouri-Columbia

Richard Madsen

University of Missouri-Columbia

Karen Hayes

Wichita State University

Gilbert Ross, Jr

University of Missouri-Columbia

The purpose of this prospective descriptive study was to explore the patterns of intrasubject (between medication) adherence of two similarly timed, twice-daily medications using the Medication Event Management System® electronic monitoring cap. Medication adherence was measured for 6 months using electronic monitoring in 25 adult renal-transplant recipients. Data were available from 7,119 electronic medication events. Results indicated that two twice-daily medications scheduled to be taken simultaneously were taken within 5 min of each other 77% of the time and within 10 min, 92% of the time. When only the first scheduled dose of the day was examined, the results are 79% and 95%, respectively. These findings are important to researchers and clinicians who must evaluate medication adherence in transplant recipients while balancing cost and subject burden. This study provides empirical support for monitoring a single immunosuppressive medication electronically to estimate medication adherence with double or triple immunosuppressive drug therapy.

Key Words: medication adherence • transplantation • patterns


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